Global challenges, including resource inefficiency, rising food demand, sustainability concerns, and climate change, necessitate more efficient and resilient agricultural systems. Conservation agriculture (CA), which is based on the principles of the minimum mechanical soil disturbance, permanent soil organic cover, and species diversification, provides a promising solution. This study examined the principles and mechanisms of CA, assessed its benefits and constraints, and identified key research gaps. This study focused on CA outcomes related to soil health, biodiversity, productivity, and ecosystem services, considering factors such as climate, soil type, and management practices. CA has demonstrated the potential to improve soil health, enhance biodiversity, and boost productivity across diverse regions. However, its effectiveness has been found to vary across studies, emphasizing the need for a more critical understanding of its benefits and limitations. Moreover, variations in outcomes are evident due to differences in experimental methodologies, environmental conditions, and socioeconomic factors. For the widespread adoption of CA practices, it is necessary to make personalized adjustments to it, integrating the corresponding technologies, thereby meeting the needs of farmers. Interdisciplinary research is crucial to refining CA practices and addressing existing knowledge gaps. This study is practiced to enhance the understanding of the potential of CA to promote a sustainable global food production system.